MAPK1 and granular corneal dystrophy type II: Relative researches had demonstrated the NF-κB activation response to the cytokines [38], ERK activation [35], and TLR4 activation [39], while most of study of NF-κB system concentrated on the discussion of IL-1 and TNF-α; those had been widely confirmed as the key initiating factor for NF-κB pathway in the inflammation response of ACD [40–42].