Consistent with the higher percentage of CCR4+CD45RA−CD45RO+CCR7+ CD4+ T cells in patients without blood eosinophilia (Fig. 4a), atopic asthma patients without blood eosinophilia showed an increase of CRTH2+CD45RA−CD45RO+CCR7+ CD4+ T cells, compared to control subjects (Fig. 5d). This evidence concerns the gene CCR4 and Increased total eosinophil count.