HTT and amyotrophic lateral sclerosis: These cellular inclusion bodies include Mallory–Denk bodies, intracytoplasmic hyaline bodies, and α1 antitrypsin aggregates in the liver; and Lewy bodies, neurofibrillary tangles, and huntingtin aggregates in the brain.1, 2 Mutations in p62 have been identified as the cause of various disease including Paget’s disease of bone (PDB) and amyotrophic lateral sclerosis (ALS).3 Although the precise role of p62 in these disease is not fully understood, impaired autophagy has been suggested to contribute to at least in part to the underlying pathogenic mechanism.