Examples are characterizing chromosomal translocations t(15;19) NUT-BRD4 in NUT carcinoma, t(11;22) EWSR1-FLI1 in sinonasal Ewing sarcoma/PNET and chromosomal rearrangements involving PAX3 Biphenotypic sinonasal sarcoma15–18. The gene discussed is EWSR1; the disease is primitive neuroectodermal tumor.