A smaller number of these miRNAs target pro-apoptotic proteins, such as apoptosis protease activating factor-1 (MiR-27b59), and repressors of dendritic/synaptic growth including the polycomb group protein Bmi1 (MIR-27b60), and the Schizophrenia-associated gene Quaking (MiR-214 (ref. 61)). This evidence concerns the gene BMI1 and schizophrenia.