Disease-specific cargo of EVs include the prion protein in spongiform encephalopathy11, tau and amyloid-β1-42 (Aβ1-42), ceramide and PAR4 in models of Alzheimer’s Disease (AD)12–16, α-synuclein and LRRK2 in rodent models of Parkinson’s disease17, 18 superoxide dismutase1 (SOD1) in rodent models of Atrophic Lateral Sclerosis19, and neurotoxic HIV-1 proteins in cell models of infection and neurodegenerative disease20, 21. The gene discussed is MAPT; the disease is Alzheimer disease.