Significantly, systemic neutralisation of PD-L2 or FASL activity supported decreases in tumour volume (Fig. 4g, i) and coincident enhanced infiltration of antigen-specific CD8+ T cells (Fig. 4h, j) in the absence of effects in immune or stromal compartments (Supplementary Fig. 6a–i). This evidence concerns the gene PDCD1LG2 and neoplasm.