NPM1 and acute myeloid leukemia: Translocation in the NPM1 gene has been reported for several hematopoietic malignancies25,26; for example, t(2;5)(p23;q35) in 75% of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma27, t(5;17)(q35;q31) in less than 1% of acute promyelocytic leukemia28, and t(3;5)(q25;q35) in less than 1% of acute myeloid leukemia (AML)26.