SMAD4 and Behcet disease: Other differentially expressed genes in the canonical pathway included several members of the β-catenin destruction complex (FRAT2 decreased in SCZ, CSNK2A2 decreased in BD, and CSNK2B increased in both), degradation complex (CACYBP and FBXW11 decreased in SCZ, and CUL decreased and RBX1 increased in BD), and nuclear regulation of β-catenin (CHD8 increased in SCZ, CTBP1 and MAP3K7 decreased in SCZ, and CREBBP and SMAD4 decreased in both).