Interestingly, although CASZ1 was reported to promote cell migration and invasion via EMT in ovarian cancer [22], however, in this study, we found that altering CASZ1 expression in HCC cells had no significant effects on the EMT gene expression and cell morphologic changes, indicating the role of CASZ1 in HCC progression was EMT-independent. Here, CASZ1 is linked to hepatocellular carcinoma.