As the downstream effectors of p-ERK, MMP2 and MMP9 are important for tumor invasion and metastasis by degrading basement membrane components [40], while cyclinD1 acts on G1-S progression of the cell cycle [41], thus they may decipher the function of CASZ1 in HCC proliferation and metastasis. This evidence concerns the gene MMP9 and hepatocellular carcinoma.