As LGCCs are only expressed in excitable cells, and our data in Fig. 1e and f also showed that TNFα had no effect on the level of cytosolic Ca2+ in cells cultured in calcium-free medium, so the effects of LGCCs and SOCEs on TNFα-mediated Ca2+ influx in HCC cells were ruled out. The gene discussed is TNF; the disease is hepatocellular carcinoma.