The levels of GluA1, phosphorylation of GluA1 at ser845 site (p-GluA1-Ser845), and GluN2B were enhanced in the BLA of PPD models (GluA1: F(4,25) = 3.285, P = 0.072, LSD test; p-GluA1-Ser845: F(4,25) = 3.687, P = 0.061, Dunnett T3 test; GluN2B: F(4,25) = 4.431, P = 0.077, LSD test, Fig. 4b, c, and f), which were reversed by ZBD-2 administration (Fig. 4b, c, and f). Here, GRIN2B is linked to progressive pseudorheumatoid arthropathy of childhood.