After adjustment for age, gender, DM, HTN, BMI, systolic blood pressure, eGFR, hemoglobin, phosphorus, corrected calcium, and FGF23, serum klotho had a significant inverse association with LVMI (β - 0.04; 95% CI -0.004, − 0.00007; P = 0.041; Table 2). This evidence concerns the gene FGF23 and hypertensive disorder.