The authors explained that downregulation of the stress-induced transient receptor potential canonical 6 (TRPC6)-mediated gene amplification loop by soluble klotho may play a role in the cardioprotection of uremic hearts [36].Yang et al.[16]reported that klotho protects against indoxyl sulphate-induced cardiac hypertrophy in CKD mice. The gene discussed is KL; the disease is cardiac hypertrophy.