Consistent with this Alsop et al. indicated that in their Australian cohort 8 of the 10 designated endometrioid cancer patients and 3 of 4 clear cell cancer patients identified with BRCA1 or BRCA2 mutations were reclassified as HGSC following immunohistopathology review, so that considerably less than 5% of patients with either endometrioid or clear cell carcinoma were found to have a germline BRCA mutation [9]. This evidence concerns the gene BRCA1 and clear cell adenocarcinoma.