APP and early-onset autosomal dominant Alzheimer disease: Increased levels of amyloid-β precursor protein (APP) (Sheng et al., 1994) and age-accelerated presence of senile amyloid plaques (Mackenzie and Miller, 1994) have been observed in temporal lobectomy tissue from older TLE cases and seizures are particularly prevalent in patients with Alzheimer’s disease with APP duplication compared to other dominant Alzheimer’s disease genetic mutations (Zarea et al., 2016).