Although our previous study showed that several established target genes of canonical Wnt signalling were induced in the neuroblastoma cell lines treated with Wnt3a/Rspo2, including AXIN2 and LEF1, we found that SOX2, MYC and MYCN, which were shown to be Wnt pathway target genes studies in other tissue systems (http://web.stanford.edu/group/nusselab/cgi-bin/wnt/), did not exhibit strong induction. The gene discussed is RSPO2; the disease is neuroblastoma.