Analysis of genes that are increased with retinoic acid induced differentiation of neuroblastoma cells (NGRF, NF68, NTRK1, SYP, MAP2, NEFM, DKK2) [45], [46], [47] showed that all were elevated after 72 hours Wnt3a/Rspo2 treatment. The gene discussed is NTRK1; the disease is neuroblastoma.