In neuroblastoma, mutations in Wnt pathway components have only been reported very recently [20], and identified mutations predicted to have high functional impact in a Wnt geneset defined by the KEGG database, and included NFATC1, FBXW11, TP53, AXIN2, LRP5, CCND1, FZD9, DVL2, FOSL1, WNT7B, VANGL1, LEF1, and PPP3CB genes. The gene discussed is LEF1; the disease is neuroblastoma.