The tumor suppressor APC, listed on top, interacts with AXIN1, which, in addition, interacts with other Wnt/ß-catenin signaling pathway components [62] and is essential for degradation of ß-catenin in the Wnt/ß-catenin signaling cascade, an important signal transduction pathway in CRC [63]. The gene discussed is APC; the disease is colorectal carcinoma.