E2F4 and colorectal carcinoma: In addition, a comparison between the DIRAGs (Table S1) with the CRC defined gene list (Table S6, 48 genes) showed that 7 known CRC genes were part of the list, namely APC, ARID1A, AXIN1, E2F4, MSH2, PMS2, and TP53. The tumor-suppressor gene APC is also associated with AXIN1 in the WNT signaling pathway, which is a crucial colorectal tumorigenesis signal transduction pathway [46].