In various model organisms and cell systems, ATP13A2 renders protection against well-known genetic and environmental risk factors of PD, such as α-synuclein toxicity [5] and Fe3+- [31], Zn2+- [6, 7, 11] or Mn2+-toxicity [10, 13, 14, 32, 33], respectively. This evidence concerns the gene ATP13A2 and Parkinson disease.