A biopsy of the submandibular lesion showed an aggressive B- lymphoma, with features compatible with an Epstein–Barr virus (EBV) (-) DLBCL non-otherwise specified (DLBCL-NOS, WHO 2008), with immunomorphological features of postgerminal center activated B cells [ABC, CD20+, CD79a+, PAX-5+. This evidence concerns the gene ABCB6 and diffuse large B-cell lymphoma.