By completely inhibit decomposability of cyclic guanosine monophosphate (cGMP), PDE5 inhibitors are expected to result in relaxation of smooth muscle and maintain penile erection.[1] Thus, it helps erectile dysfunction (ED) patients in maintaining a normal erection, and decreases pulmonary vessels’ pressure in pulmonary vasculature vasodilatation. Here, PDE5A is linked to erectile dysfunction.