The lack of detection of the causing microorganisms can worsen patient outcome increasing hospital length of stay and costs.[5] Inflammatory markers such as C-reactive protein (CRP) and procalcitonin (PCT) have been previously evaluated in the diagnosis of bacterial infection.[6,7] Although used for many years, CRP specificity in the diagnosis of bacterial infections versus inflammation has been often questioned.[7–10] CRP is an acute phase protein promptly released during inflammation condition. This evidence concerns the gene CRP and bacterial infectious disease.