Interestingly, inhibition of p300 significantly reduced HW/TL ratio, and wall thickness, while increasing ejection fraction in SIRT2-deficient mice (Figure 5I–K), indicating that p300 inhibition rescues cardiac hypertrophy and contractile dysfunction resulting from SIRT2 deficiency, which could be due to the restoration of GSK3 activity. The gene discussed is EP300; the disease is cardiac hypertrophy.