In CRC, redirection of glucose metabolism is promoted by deregulation of key components involved in glucose transport (GLUT-1) [36], metabolism (hexokinases [HK1, HK2], pyruvate kinase M2 [PKM2], lactate dehydrogenase A [LDHA], aldolase A [ALDOA], etc.)[37–39], as well as metabolic regulation [40–42]. Here, PKM is linked to colorectal carcinoma.