We used histological and electron-microscopic analyses to evaluate cerebrovascular alterations during development of the signs of AD in OXYS rats, a bioinformatic analysis of RNA-Seq data to identify the metabolic processes and pathways involved in the development of cerebrovascular dysfunction, and quantification of vascular endothelial growth factor (VEGF), which is a neuroprotective cytokine promoting neurogenesis and angiogenesis in the brain. This evidence concerns the gene VEGFA and Alzheimer disease.