Next, we assessed the expressions of the 12 lncRNA in 92 serum samples (46 NSCLCs and 46 healthy controls) and identified two lncRNA [SOX2 overlapping transcript (SOX2OT) and ANRIL] that were overexpressed in tumor serum samples compared with healthy controls (Table S3, all at P < 0.01). The gene discussed is SOX2; the disease is neoplasm.