Among MMPs, MMP‐2 and MMP‐9 play important roles for basement membrane type IV collagen degradation during cancer progression, especially for promoting tumour migration and invasion.88 These two MMPs are well expressed in human PCa and PCa cell lines 89, 90 where their expression levels positively correlate with metastatic disease.59 In the present study, we also demonstrated, for the first time, that Glo1/MG‐H1‐AP/TGF‐β1/Smad axis controls MMP‐2 and MMP‐9 expression and activity. Here, DHCR7-DT is linked to cancer.