One of the major anti‐invasive effects of miR‐101 involves the histone methyltransferase enhancer of zeste homolog 2 (EZH2).74 Among the EMT‐associated genes evaluated in our study (E‐cad, ZO‐1, vimentin, N‐cad and Snail), only E‐cad and Snail seem to be indirectly regulated by miR‐101, via its regulation of EZH2.94, 95, 96, 97, 98, 99, 100 To our knowledge, this is the first demonstration of the direct negative regulation of these EMT‐associated genes by miR‐101 in PCa. Here, EZH2 is linked to posterior cortical atrophy.