Previous studies have identified several factors associated with eradication resistance, including t(11;18)(q21;q21)/API2–MALT1 translocation, absence of H. pylori infection, advanced clinical stage, deep submucosal invasion, and proximal localization in the stomach.15, 23, 24, 25 In this study, only 1 patient was positive for t(11;18)(q21;q21)/API2–MALT1 translocation, all patients were H. pylori‐positive, 98% (95/97) showed stage I MALT lymphoma, and 10% (10/97) exhibited invasion beneath the submucosa. This evidence concerns the gene MALT1 and MALT lymphoma.