Concerning DNA hypomethylation, transcription factors such as FOS, JUN, and JUND were detected at both cancer and aging hypomethylated CpG sites, but again aging displayed stronger and more varied enrichment, and included the presence FOSL1/2, other bZIP‐domain factors like MAFF and MAFK, and STAT3, which has been associated with recruitment of the H3K4 methyltransferase SET9 at promoters (Yang et al., 2010). The gene discussed is MAFF; the disease is cancer.