NLRP3 and infection: For example, EseG is involved in microtubule depolymerization (Xie et al., 2010; Fang et al., 2016), EseJ helps E. piscicida proliferate in the cell (Xie et al., 2015), EseH inhibits MAPK activation via phosphothreonase activity to promote infection (Hou et al., 2017), and EvpP promotes bacterial colonization by inhibiting NLRP3 inflammasome activation (Chen et al., 2017).