FOXO4 and Hypocalcemia: The results from our mapping analyses are also consistent with previous findings: miR-218 has a regulation effect by stimulating the Wnt pathway (Hassan et al., 2012); activation of the NFAT factor is calcium-dependent, and hypocalcemia is associated with impaired insulin secretion (Pittas et al., 2007); the FOXO4 factor binds to insulin-response elements, and insulin can induce phosphorylation of FOXO4 and inhibit FOXO4-dependent gene transcription (Kops et al., 1999).