Interestingly, it has been suggested that LINE-1 elements may contribute to the pathogenesis of autoimmune disorders such as Systemic Lupus Erythematosus (SLE) (Crow, 2010; Nakkuntod et al., 2011), which is known to involve activation of the IFN response (Bronson et al., 2012; Elkon and Wiedeman, 2012). Here, IFNA1 is linked to systemic lupus erythematosus.