In contrast to these reports, the inhibitory effect of IGFBP-6 attenuated by intracellular interaction with the LIM mineralizing protein in both human and mouse osteoblastic cells (128), and one study reported a stimulatory effect of IGFBP-6 on DNA synthesis and mitogenesis in the human osteosarcoma Saos-2/B-10 cell line (129). The gene discussed is IGFBP6; the disease is osteosarcoma.