Thus, Drp1 knock-out mice display embryonic lethality, increased mitophagy and dilated cardiomyopathy, associated with increased levels of necrotic cell death, as well as abnormal brain development and failure to develop synapses (Ishihara et al., 2009; Wakabayashi et al., 2009; Song et al., 2015). This evidence concerns the gene DNM1L and dilated cardiomyopathy.