OPA1 and Charcot-Marie-Tooth disease type 2A1: Of note, germline mutations in Mfn2 cause Charcot–Marie–Tooth hereditary-like neuropathy type 2A (CMT2A), while germline mutations in OPA1 causes the autosomal dominant optic atrophy (ADOA) which is the most common genetic cause of optic atrophy in humans (Knott and Bossy-Wetzel, 2008).