The observed gene modulation was independent of the tumor subtype and 12 among the 50 most significantly up-regulated (P < 0.00252; fold changes 1.22 < x < 9.36; Table S1) genes were selected for validation, including: MX2, CHI3L1, GREM1, LOXL2, GJA1, ITGA11, IFITM1, BST2, ADAMTS12, LOX, FIGF and IL6 (Fig. 3B). This evidence concerns the gene LOX and neoplasm.