SNCA and multiple system atrophy: For example, recent in vitro studies highlighted the role of autophagy and defective intracellular clearance in alpha‐synuclein toxicity.59, 61, 62 Valera and colleagues targeted a specific regulator of autophagy, microRNA‐101, in order to create a model of MSA and to identify potential therapeutic agents.61 iPSCs can be differentiated into many cell types and thus it could be possible to study degenerative pathways both in affected neurons and in oligodendrocytes.