TPPP and multiple system atrophy: Subsequently, Kragh and colleagues obtained a successful model of glial degeneration by co‐expressing human alpha‐synuclein and p25alpha in a rat oligodendroglial cell line, using the vector pET‐11d.106 As explained above, p25alpha appears to be implicated in early myelin dysfunction in MSA and to induce alpha‐synuclein aggregation.39 In their study, they observed that coexpression of alpha‐synuclein and p25alpha caused a retraction of microtubules from the cellular processes to the perinuclear region after the transfection.