Early myelin dysfunction is suggested by the finding that p25alpha (TPPP), usually found in myelin sheaths, relocates in the oligodendrocyte soma in the first stages of the disease.38 Moreover, the co‐localization of p25alpha and MBP is noticeably decreased in MSA brains, and total MBP content is reduced. The gene discussed is MBP; the disease is multiple system atrophy.