SNCA and multiple system atrophy: May and colleagues also developed a cellular model of MSA by overexpressing human wild‐type alpha‐synuclein in a rodent oligodendroglial cell line, GC4.69 The expression of alpha‐synuclein was shown to impair oligodendrocyte progenitor cells (OPCs) maturation, as human alpha‐synuclein‐expressing oligodendrocytes demonstrated abnormal branching, a lower number of MBP positive cells and a reduced intracellular MBP content at the final stages of differentiation compared to controls.