Demyelination plays an important role in advanced MSA,33 and recent studies found that intracellular alpha‐synuclein delays oligodendrocytes maturation and myelination by downregulating myelin‐gene regulatory factor and myelin basic protein (MBP).44, 69 Myelin dysregulation is often followed by axonal degeneration,36 as demonstrated by transgenic animal models.70, 71. Here, MBP is linked to multiple system atrophy.