KIF2C and supranuclear palsy, progressive, 1: Indeed, the C‐terminal tyrosine on α‐tubulin can act as a binary ON/OFF switch for the recruitment of MT dynamics regulators, such as kinesin 13 MCAK, which preferentially depolymerizes tyrosinated MTs.41 In addition, the C‐terminal tyrosine is also required for the recruitment of MT plus‐end‐interacting proteins, such as cytoplasmatic linker protein‐170 (CLIP170).42 Therefore, the increasing amount of tyrosinated α‐tubulin that we observed in PSP cells could, in turn, alter the interactions with various MIPs.