Inhibitory checkpoint receptors (IR) expressed on activated immune cells such as cytotoxic T lymphocyte antigen 4 (CTLA4) and its ligands CD80 and CD86, and program death 1 (PD1) and its ligands PD-L1 and PD-L2, play an important role in the tumor microenvironment (TME) [8].Often expression of these inhibitory receptors signifies an exhausted T cell that has lost its normal function, including reduced proliferative capacity or cytolytic activity. The gene discussed is CD274; the disease is neoplasm.