Up-regulation of CXCL1 and CXCL8 mRNA was also seen in other single cell clones isolated from BPH-TW1 and BPH-TW3, but not in single cell clones isolated from BPH-TW2 (Supplementary Fig. 4 b, c). The gene discussed is CXCL8; the disease is benign prostatic hyperplasia.