CXCL8 and neoplasm: Our studies demonstrate that activation of the IL-1α pathway increases expression of CXCL8 in myeloid-driven BPH-1 tumor cells and that inhibition of the pathway leads to decreased angiogenesis and reduced tumor growth, suggesting that myeloid cells are able to activate the IL-1α pathway in genetically primed prostate epithelial cells, resulting in expression of CXCL8 and increased angiogenesis, which contributes to malignant transformation and tumor growth (Fig. 6e).