Our studies demonstrate that activation of the IL-1α pathway increases expression of CXCL8 in myeloid-driven BPH-1 tumor cells and that inhibition of the pathway leads to decreased angiogenesis and reduced tumor growth, suggesting that myeloid cells are able to activate the IL-1α pathway in genetically primed prostate epithelial cells, resulting in expression of CXCL8 and increased angiogenesis, which contributes to malignant transformation and tumor growth (Fig. 6e). Here, IL1A is linked to neoplasm.