Though both studies show different phenotypes, they both implicate polycystin 1 as a modulator of the Wnt pathway, mainly inhibiting glycogen synthase kinase (GSK-3β) which normally phosphorylates beta-catenin for subsequent degradation [90, 91].However, the approach of Low et al. may better recapitulate the renal cyst formation seen in autosomal dominant polycystic kidney disease. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.