In this study, we intend to illuminate: (a) Evaluate the role of IGFBP2 in prognosis and chemoresistance in lung cancer; (b) Detect the effect of IGFBP2 on cell viability and reveal the therapeutic effect of histone deacetylase inhibitors (HDACi) on cisplatin-resistant cell lines; (c) Evaluate the role of autophagy in reversing chemoresistence. The gene discussed is IGFBP2; the disease is lung cancer.