Combined with our results, we concluded as follows: (1) It is likely that IGFBP2 is one of autocrined hormones to activate other signal transduction, (2) IGFBP2 may regulate epithelial-mesenchymal transition and VEGF to promote tumor formation and progression; (3) IGFBP2 plays an important role in tumor migration and invasion. Here, IGFBP2 is linked to neoplasm.