Likely, Ranke MB et al. have revealed that IGFBP2 plays an important role in signal transduction and metabolic homeostasis in tumors, including exert an autocrine effect on cancer cells and paracrine effects on endothelial cells and other mesenchymal cells16; Additionally, IGFBP2/integrin/ILK/NF-κB network was one key player in glioma progression17, intracellular IGFBP2 could regulate caspase-3 expression and contribute to the inhibitory effect on apoptosis18. This evidence concerns the gene IGFBP2 and central nervous system cancer.