ACAT2 and amyotrophic lateral sclerosis: Accordingly, another protein strongly over-represented in ALS mice motor neurons was acetyl-CoA acetyltransferase 2 (ACAT2), which catalyzes the reversible conversion of two units of acetyl-CoA to acetoacetyl CoA (ketogenesis) or the thiolytic cleavage of 3-ketoacyl-CoA into two-carbon chain-shortened acyl-CoA plus acetyl-CoA (ketosis).