HADHB and amyotrophic lateral sclerosis: In particular, our study revealed a potential biomarker that is increased in both ALS mice motor neurons and patients’ skin fibroblasts: HADHA, the trifunctional enzyme complex subunit alpha located in the mitochondria, also known as hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase.