The protein lysate from tumor tissues indicated that both LC3 and Beclin-1 expressions were downregulated in combined BZM-2-APB group compared to BZM treatment alone, these findings further supported that the mechanism of sensitizing the anti-tumor effect of BZM was mediated by 2-APB autophagy suppression (Fig. 6d). This evidence concerns the gene MAP1LC3A and neoplasm.