SIPA1 and chronic myelogenous leukemia, BCR-ABL1 positive: Thus, analysis using BM chimeric mice indicated that neither <Wt BM into Sipa1−/−>mice nor <Sipa1−/−BM into Wt>mice showed strong CML resistance comparable to that of <Sipa1−/− BM into Sipa1−/−>mice, suggesting that the combination of Sipa1−/− T cells and Sipa1−/− nonhematopoietic cells is essential for the complete rejection.