Expression of SESN2 was stimulated by genotoxic stress via tumor suppressor p5342,45 in HEK293 and MCF-7 cells; by glucose starvation through activation of transcription factor 4 (ATF4) and nuclear factor (erythroid-derived 2)-like 2 (NRF2) transcription factors43,46 in human lung adenocarcinoma H1299 and H460 cell lines and MEF; and by AA deprivation acting through GCN2, ATF4 in MEF cells47. This evidence concerns the gene ATF4 and lung adenocarcinoma.