LY6E and dilated cardiomyopathy: Deletion of Ly6e, a member of the Ly6 superfamily22–26 and also known as stem cell antigen 2 (SCA2), retinoic acid induced gene E (RIGE), and thymic shared antigen 1 (TSA1), results in embryonic lethality at mid-gestation (E15.5), reportedly due to dilated cardiomyopathy and heart failure27.