Because of the apparently orthogonal nature of SI and PD-L1 expression from the TCGA analysis, and the role of PD-L1 in tumor immune evasion, we investigated whether epithelial PD-L1 protein expression as determined by immunohistochemistry (IHC, see Materials and Methods) modified the prognostic value of the SI score in our TMA cohorts. This evidence concerns the gene CD274 and neoplasm.