BACE1 and Alzheimer disease: The expression of BACE1-AS in the brain of AD patients is upregulated, suggesting that BACE1-AS may play a role in the pathogenesis of AD.21, 22 Studies have shown that BACE1-AS can bind to BACE1 mRNA, increase the stability of the latter, thereby promoting the synthesis of BACE1 protein,21 and further increase the production of Aβ of cells.