SOD1 and amyotrophic lateral sclerosis: Studies have shown that abnormal accumulation of FUS/TLS and TDP43 in the cytosol directly leads to the misfolding of wtSOD1 (wild-type Cu/Zn superoxide dismutase) in non-SOD1 FALS (familial ALS) and SALS (sporadic ALS), which means that they constitute common molecular pathogenesis mechanisms of ALS.59