LCN2 and myeloid sarcoma: One particularly notable vector is the secretion of the iron-trafficking protein Lipocalin 2 (Lcn2), which is canonically associated with innate immune responses but also described to act as a neuroinflammatogen in many CNS pathologies, including SCI and MS.11, 12 Astrocyte-secreted Lcn2 is known to exacerbate neuroinflammation by inducing pro-inflammatory polarization in recipient astrocytes and microglia, even promoting cell death in neurons.13