LCN2 and demyelinating disease: Knockout of Lcn2 has been found to largely negate the pro-inflammatory polarization of activated astrocytes in vitro and in vivo,21, 22 yielding better histopathological outcomes in mouse models of stroke, demyelinating diseases, or SCI.11, 23, 24, 25Lcn2-deficient (Lcn2−/−) mice display remarkable neuronal survival and myelin sparing after contusion SCI.11