Ostensibly involved in iron regulation and the innate immune response, Lcn2 is upregulated/secreted by reactive astrocytes21, 22, 56, 57, 58, 59 and has been implicated in the modulation of inflammation in a number of CNS disorders, including SCI,11 MS,25, 60, 61, 62 and Parkinson’s disease.63 This evidence concerns the gene LCN2 and central nervous system disorder.