In addition, immunostaining for anti-PHF-Tau and anti-Aβ revealed the presence of a variable amount of immunoreactive PHF-Tau neurons and Aβ-plaques in the AD cases, whereas in control cases no Aβ-plaques were found and only occasional PHF-Tau neurons were present (Figs. 1, 2, and 3; Table 1). This evidence concerns the gene MAPT and Alzheimer disease.