In patients infused with CTL119 (humanized anti-CD19 CAR) after prior therapy with murine-derived CD19-targeted CAR T cells, grades 1–3 CRS, per the Penn grading scale, occurred in four of eight patients (50%) and correlated with efficacy and disease burden similar to our experience with tisagenlecleucel; no grade 4 CRS was observed after retreatment with CTL119 [22]. Here, CD19 is linked to congenital rubella syndrome.