Thus, in this study of 23 LC patients, we detected COL7A1-UCN2 in 13 patients (57%), and a comparison of the positive TIC distribution in the LC and ANMMT samples demonstrated that positive LC samples were statistically significantly more common than positive ANMMT samples (p < 0.0001) (Fig. 3b). This evidence concerns the gene UCN2 and laryngotracheoesophageal cleft.