Furthermore, in CRC cell lines, the blockage of the UCN2/CRFR2 axis promoted EMT (the altered expression of EMT marker, decreased vimentin, and increased E-cadherin and glycogen synthase kinase 3β expression) via persistent interleukin-6/Stat3 signaling (colonic inflammation regulation) [21]. This evidence concerns the gene STAT3 and colorectal carcinoma.