CRHR2 and neoplasm: The activation of the UCN2/corticotropin-releasing factor receptor 2 (CRFR2) axis signaling can inhibit tumor vascularization, cell proliferation and invasion, and EMT [21, 47], whereas the mechanism of COL7A1-UCN2 chimera generation can potentially down-regulate UCN2 mRNA and thereby cause the loss of its tumor suppressor role.